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Phagolysosome membrane rupture can trigger a maladaptive immune response that promotes tissue damage. In Science, Cantuti-Castelvetri et al. (2018) report that cholesterol-rich myelin debris overwhelms reverse cholesterol transport in aged phagocytes,… Click to show full abstract
Phagolysosome membrane rupture can trigger a maladaptive immune response that promotes tissue damage. In Science, Cantuti-Castelvetri et al. (2018) report that cholesterol-rich myelin debris overwhelms reverse cholesterol transport in aged phagocytes, leading to cholesterol crystal formation, damaged phagolysosomes, and limited tissue repair.
Keywords:
phagolysosomal damage;
cholesterol;
damage;
heart phagolysosomal;
cholesterol heart;
high cholesterol
Journal Title: Cell metabolism
Year Published: 2018
Link to full text (if available)
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Journal Title: Cell metabolism
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!