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Mutations in mtDNA associated with OXPHOS defects preclude energy harnessing by OXPHOS. The work of Chen et al. (2018) is previewed, reporting flux pathways of glutamine catabolism in mtDNA mutant cells… Click to show full abstract
Mutations in mtDNA associated with OXPHOS defects preclude energy harnessing by OXPHOS. The work of Chen et al. (2018) is previewed, reporting flux pathways of glutamine catabolism in mtDNA mutant cells yielding high-energy phosphates through substrate-level phosphorylation and the influence exerted by the severity of OXPHOS impairment.
Keywords:
glutamine rescue;
due mtdna;
defects due;
oxphos defects;
mtdna mutations;
mutations glutamine
Journal Title: Cell metabolism
Year Published: 2018
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Journal Title: Cell metabolism
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!