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Compelling evidence indicates that tumors may evade immunosurveillance by subverting the metabolism of immune cells. In a recent paper in Nature, Song et al. (2018) demonstrate that ovarian cancers activate IRE1α-XBP1 signaling… Click to show full abstract
Compelling evidence indicates that tumors may evade immunosurveillance by subverting the metabolism of immune cells. In a recent paper in Nature, Song et al. (2018) demonstrate that ovarian cancers activate IRE1α-XBP1 signaling within CD4+ T lymphocytes, thereby disrupting their bioenergetic function and contribution to anticancer immune responses.
Keywords:
induced endoplasmic;
endoplasmic reticulum;
reticulum stress;
stress cells;
cancer induced;
immunosurveillance
Journal Title: Cell metabolism
Year Published: 2018
Link to full text (if available)
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Journal Title: Cell metabolism
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!