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Cancer cells must adapt to metabolic stress during tumor progression. In this issue of Cell Metabolism, Eichner et al. (2019) report that lung cancer development in genetically engineered mice requires the… Click to show full abstract
Cancer cells must adapt to metabolic stress during tumor progression. In this issue of Cell Metabolism, Eichner et al. (2019) report that lung cancer development in genetically engineered mice requires the energy sensor AMP-activated protein kinase (AMPK). Their findings suggest that AMPK-mediated induction of lysosomal function supports cancer cell fitness, particularly during the early stages of tumorigenesis.
Keywords:
mediated lysosome;
biogenesis lung;
lung cancer;
lysosome biogenesis;
ampk mediated;
cancer
Journal Title: Cell metabolism
Year Published: 2019
Link to full text (if available)
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Journal Title: Cell metabolism
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!