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Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword.

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Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as… Click to show full abstract

Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.

Keywords: wields double; pyruvate carboxylase; carboxylase; carboxylase wields; double edged

Journal Title: Cell metabolism
Year Published: 2019

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