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Cells utilize multiple mechanisms to support endoplasmic reticulum (ER) function. The unfolded protein response, UPRER, is engaged during proteotoxic challenges to either mitigate ER stress or promote apoptosis. In a… Click to show full abstract
Cells utilize multiple mechanisms to support endoplasmic reticulum (ER) function. The unfolded protein response, UPRER, is engaged during proteotoxic challenges to either mitigate ER stress or promote apoptosis. In a CRISPR-based genetic screen, Schinzel et al. (2019) identified TMEM2 as a mediator of ER stress tolerance independent of the individual branches of the canonical UPRER and linked this path to nematode longevity.
Keywords:
tmem2 modulates;
modulates stress;
tmem2;
non canonical;
stress non;
canonical manner
Journal Title: Cell metabolism
Year Published: 2019
Link to full text (if available)
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Journal Title: Cell metabolism
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!