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SGLT-2 Inhibitors and Circulating Progenitor Cells in Diabetes.

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Hess et al. recently hypothesized that shifts in circulating progenitor cell populations may drive cardiovascular protection by SGLT-2 inhibitors in patients with type 2 diabetes. In this Letter, Fadini challenges that… Click to show full abstract

Hess et al. recently hypothesized that shifts in circulating progenitor cell populations may drive cardiovascular protection by SGLT-2 inhibitors in patients with type 2 diabetes. In this Letter, Fadini challenges that interpretation and discusses previous findings from an independent randomized placebo-controlled trial indicating that cardiovascular protection by SGLT-2 inhibitors may not directly involve circulating stem/progenitor cells.

Keywords: progenitor cells; circulating progenitor; inhibitors circulating; sglt inhibitors; cells diabetes; progenitor

Journal Title: Cell metabolism
Year Published: 2020

Link to full text (if available)


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