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A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion.

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Akkermansia muciniphila is a gut commensal known to improve host metabolism. The outer membrane protein Amuc_1100 has been shown to partially replicate these beneficial effects. Here, Yoon et al. (2021) have… Click to show full abstract

Akkermansia muciniphila is a gut commensal known to improve host metabolism. The outer membrane protein Amuc_1100 has been shown to partially replicate these beneficial effects. Here, Yoon et al. (2021) have identified a novel protein (P9) secreted by A. muciniphila that stimulates GLP-1 secretion, thereby adding new insight to the biomolecule era to treat metabolic diseases.

Keywords: akkermansia muciniphila; glp secretion; stimulates glp; muciniphila stimulates

Journal Title: Cell metabolism
Year Published: 2021

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