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Abstract Epigenetic modifications play an important role in regulating gene expression among a host of other factors during cell development. The plasticity of epigenetic modifications has the potential to direct… Click to show full abstract
Abstract Epigenetic modifications play an important role in regulating gene expression among a host of other factors during cell development. The plasticity of epigenetic modifications has the potential to direct a cell in relation to environmental factors to its destined state. Therefore, understanding different epigenetic states is crucial for dissecting the gene regulatory mechanisms. With the recent advances in single-molecule tools, monitoring the dynamics of epigenetic regulation and quantification has become possible. In this review, we discuss the recent advances in single-molecule fluorescence tools in gaining new insights into the epigenetic regulation and its relation to chromatin conformation.
Journal Title: Current Opinion in Biomedical Engineering
Year Published: 2019
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