LAUSR

Since its discovery in 1886, bacterial-derived cellulose has become a highly researched biomaterial due to its unique structural properties. These properties include fibrous structure and robust stability through immense hydrogen bonding. The hydrogen bonding and resulting hierarchical structure from polymer chains to fibers can be controlled by altering bacteria culture conditions. Low temperature and static culture of cellulose producing microbes lead to the formation of a less stable cellulose amorph, while agitated culture, increased culture duration, alternative carbon sources, and the addition of additives lead to the formation of cellulose with an increased thermal stability. The unique structure of bacterial-derived cellulose allows it to be used for living cell-based sensors, vehicles for targeted cell delivery, and material for wound dressings. This review discusses the recent findings on bacterial-derived cellulose and cellulose synthase as a frame for advanced functional biomaterials.