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Abstract Protein PEGylation plays an important role in the whole panel of reactions used for the modification and improvement of therapeutic proteins. The classic production process consists of a batch… Click to show full abstract
Abstract Protein PEGylation plays an important role in the whole panel of reactions used for the modification and improvement of therapeutic proteins. The classic production process consists of a batch reactor followed by a purification unit. In this review, we show that other processes smartly combining the separation and the reaction unit operations within a single process can bring a competitive advantage in terms of yield, conversion and productivity. This represents an alternative approach to the development of new ad-hoc specific chemistries. In the following, in addition to provide an overview of processes described in the literature and discuss advantages and disadvantages of each, we propose innovative solutions which include continuous manufacturing technologies.
Journal Title: Current Opinion in Colloid and Interface Science
Year Published: 2017
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