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Abstract Self-assembly between oppositely charged polyelectrolytes conjugated to neutral polymeric blocks form polyelectrolyte complex (PEC) micelles. These nanostructures have gained significant interest in the field of nucleic acid and protein… Click to show full abstract
Abstract Self-assembly between oppositely charged polyelectrolytes conjugated to neutral polymeric blocks form polyelectrolyte complex (PEC) micelles. These nanostructures have gained significant interest in the field of nucleic acid and protein delivery, along with emerging applications in biosensing and catalysis. These carriers are highly modular systems, with the ability to engineer stimuli-responsive and targeting properties, making them smart platforms for biomedical applications. In this review, we discuss the current understanding of mechanisms involved in the assembly and disassembly of these nanoparticles, and the structural and functional changes as a response to solution conditions. We also discuss the latest and most impactful applications of PEC micellar systems in the biomedical field, with far reaching influence on the treatment of various human diseases.
Journal Title: Current Opinion in Colloid and Interface Science
Year Published: 2021
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