LAUSR

Abstract Human disease development involves a highly dynamic and interactive system of multiple layers of molecular markers (e.g. genetics, epigenetics, mRNA transcripts, proteins, and metabolites). Being aware of this, precision medicine aims to provide a detailed characterization of a disease to customize healthcare. Although high-throughput omics technologies are currently able to gather in a single experiment, large amounts of data about a specific type of molecules, it is now fully accepted that the simultaneous analysis of multiple layers of molecular markers leads to novel strategies for their early detection, prevention, and treatment of diseases. In this sense, electrochemical biosensing, also in constant evolution, shows versatility for the simultaneous monitoring of different omics layers biomarkers, using simple, affordable and short testing time devices. This article overviews, briefly and critically, through representative recent reported examples, how electrochemical biosensing can contribute and assist multiomics techniques to facilitate the advent of the eagerly awaited precision medicine as well as the challenges to face it.