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Germline stem cell aging in the Drosophila ovary.

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The age-related decline of adult stem cells leads to loss of tissue homeostasis and contributes to organismal aging. Though the phenotypic hallmarks of aging are well-characterized at the organ or… Click to show full abstract

The age-related decline of adult stem cells leads to loss of tissue homeostasis and contributes to organismal aging. Though the phenotypic hallmarks of aging are well-characterized at the organ or tissue level, the molecular processes that govern stem cell aging remain unclear. This review seeks to highlight recent research in stem cell aging in the Drosophila ovary and connect the discoveries in the fly to ongoing questions in stem cell aging.

Keywords: drosophila ovary; stem cell; aging drosophila; cell aging

Journal Title: Current opinion in insect science
Year Published: 2020

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