LAUSR

Abstract A new approach to the analysis of nonlinear surface dilational rheological properties was developed with the aim to enlarge the accessible range of surface pressures. The dilational surface elasticity of spread monolayers of DPPC, cholesterol, DMEA and their mixtures was determined in the region of low surface tensions (less than 10 mN/m) corresponding to the state of pulmonary surfactants at the lung interface. The dilational surface elasticity of pure DPPC monolayer proved to be high (∼200 mN/m) up to the collapse. The addition of cholesterol, DMEA or their mixture to the DPPC monolayer increased the dynamic surface elasticity, but could decrease significantly the surface pressure of the monolayer collapse if the concentration of additions exceeds an optimal value.