LAUSR

A Poincaré plot is a return map that geometrically elucidates the progression of a time-series. It has frequently been used in heart rate variability analyses. However, algorithms for dedicatedly dissecting the shape of this geometrical plot are yet to be established. In this study, we proposed a gridded Poincaré plot by coarse-graining the original graph and using the newly proposed one, defined two novel measures, namely gridded distribution rate (GDR) and gridded distribution entropy (GDE). The GDR essentially represents the percentage of grids with points, while the GDE estimates the Shannon entropy of the grid weight; that is, the number of points in each grid. The performances of the two measures were examined using both theoretical data with known dynamics and experimental short-term RR interval time-series, and they were compared with several existing metrics. Simulation tests demonstrated that both the GDR and GDE could distinguish among different dynamics, while all the compared methods failed. The experimental results further indicated the ability of the GDR and GDE to differentiate healthy young people from healthy aged adults as well as distinguish healthy subjects from patients with coronary artery disease. Our results suggest that the proposed GDR and GDE may better characterize the Poincaré plot in terms of differentiating between varying dynamical regimes, and between human physiological or pathological conditions. Further studies are warranted to establish their feasibility in evaluating cardiovascular functions in clinical practice.