Photo by curology from unsplash
The opening of the mitochondrial permeability transition pore (PTP) has been proposed to play a critical role in activating cell death in many settings, including cardiac ischemia and reperfusion. Although… Click to show full abstract
The opening of the mitochondrial permeability transition pore (PTP) has been proposed to play a critical role in activating cell death in many settings, including cardiac ischemia and reperfusion. Although the identity of pore forming unit of the PTP is still debated, it is generally agreed that cyclophilin D (CyPD) is a regulator of the PTP. This manuscript will focus on understanding how CyPD might regulate the PTP and how understanding CyPD might give insight about the identify and regulation of the PTP.
Keywords:
ptp;
transition pore;
mitochondrial permeability;
permeability transition
Journal Title: Current opinion in physiology
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Current opinion in physiology
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!