LAUSR

Abstract Reaction between [Pt(ophen)Cl2] and HIS was monitored and the solvolysis ( k 1 ) and Cl/HIS ligand exchange ( k 2 ) rate constants obtained. The k 1 and k 2 were (6.2 ± 0.4) × 10−5 s−1 and 52.8 × 10−2 M−1 s−1, respectively. The corresponding calculated values were 47.5 × 10−5 s−1 and 52.2 × 10−2 M−1 s−1, in agreement with the experiment. Calculations were used to establish the reactivity order for a set of amino acids: MET ∼ LYS ∼ HIS(e) > GLU ∼ ASP >> ASN ∼ GLN. In spite of the similar reactivity among MET, LYS and HIS, the thermodynamics suggests the reactions with LYS and HIS more favorable than with MET. Therefore, N-containing amino acids should be potential targets of Pt(II)-complexes in β-amyloid.