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Abstract The interactions of hydrolysis products of cisplatin and its asymmetric derivatives cis - and trans -[PtCl 2 ( i Pram)(Mepz)] with guanine were studied using DFT methods. These interactions… Click to show full abstract
Abstract The interactions of hydrolysis products of cisplatin and its asymmetric derivatives cis - and trans -[PtCl 2 ( i Pram)(Mepz)] with guanine were studied using DFT methods. These interactions are dominated by electrostatic effects, namely hydrogen bond contributions and there exists a charge flow from H-atoms of ligands to the O-atoms of guanine. The replacement of NH 3 moieties by larger functional groups accompanies with a moderate reaction between Pt II and guanine molecule, diminishing the cytotoxicity of the drug. The asymmetric and symmetric NH 2 stretching modes of complexes having strong hydrogen bond interactions are red shifted importantly as compared to complexes without presence of hydrogen bond interactions.
Journal Title: Chemical Physics Letters
Year Published: 2017
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