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Abstract The shape of two non-covalent dimers formed by different variants of the B1 domain of protein G plays an important role for their stability in water and aqueous solutions… Click to show full abstract
Abstract The shape of two non-covalent dimers formed by different variants of the B1 domain of protein G plays an important role for their stability in water and aqueous solutions [Proc. Natl. Acad. Sci. U.S.A. 115 (2018) 10965]. I demonstrate how much the stabilization afforded by the decrease in solvent-excluded volume upon association depends on the shape of the dimers in water and aqueous sugar solutions, using classic scaled particle theory. There is a strong dependence upon the decrease in water accessible surface area associated with dimer formation, whose general significance deserves attention.
Journal Title: Chemical Physics Letters
Year Published: 2020
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