LAUSR

Salivary gland carcinomas (SGC) are aggressive cancers that arise in minor and major salivary glands. Given the complexity and the multiple subtypes of this class of tumors, diagnosis and treatment may be challenging for clinicians. Recently the tumor microenvironment, composed mainly of immune, stromal cells are been a target for treatment. Accumulating evidence indicates that cancer immunotherapies have made a significant impact on oncologic patients, but in SGC immunotherapeutic attempts have been shown limited improvement. Improvements in the models that best translate aggressive SGC are needed to the development of clinical protocols grouping immunotherapies in other classes of drugs that will promote better responses in patients in advanced stages of the disease. In this review, we introduced different experimental models for SGC with a focus on tumor microenvironment highlighting potential therapy applications for each model.