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PATRIOT: A phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients with solid tumours

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Highlights • Summary of a protocol for a phase I study combining the ATR inhibitor and palliative radiotherapy.• Study design is discussed.• Study aims and objectives, brief eligibility criteria, DLT… Click to show full abstract

Highlights • Summary of a protocol for a phase I study combining the ATR inhibitor and palliative radiotherapy.• Study design is discussed.• Study aims and objectives, brief eligibility criteria, DLT criteria and dose escalation is discussed.• Brief summary of translational research to be carried out.

Keywords: phase study; atr inhibitor; study; radiation

Journal Title: Clinical and Translational Radiation Oncology
Year Published: 2018

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