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Highlights • Hyperfractionated RT with augmented dose provides durable enhanced disease control.• Late toxicity is unchanged with higher optimal doses using smaller fraction sizes.• Hyperfractionation improves overall survival but mortality… Click to show full abstract
Highlights • Hyperfractionated RT with augmented dose provides durable enhanced disease control.• Late toxicity is unchanged with higher optimal doses using smaller fraction sizes.• Hyperfractionation improves overall survival but mortality profile evolves over time.• Altered fractionation should avoid unnecessary RT protraction to maximize control.• Excessive acceleration should be avoided to minimize severe normal tissue sequelae.
Keywords:
competing mortality;
durable therapeutic;
mortality;
despite competing;
therapeutic gain;
gain despite
Journal Title: Clinical and Translational Radiation Oncology
Year Published: 2020
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Journal Title: Clinical and Translational Radiation Oncology
Year Published: 2020
Link to full text (if available)
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recommendations!