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Highlights • We evaluated the effect of the second-generation TRAIL receptor agonist APG-880 on radiation-induced cytotoxicity.• The combined effect was studied in short-term and long-term cytotoxicity assays in established CRC… Click to show full abstract
Highlights • We evaluated the effect of the second-generation TRAIL receptor agonist APG-880 on radiation-induced cytotoxicity.• The combined effect was studied in short-term and long-term cytotoxicity assays in established CRC cell lines, and tumor organoids derived from colon cancer patients.• We observed a supra-additive effect on cytotoxicity when APG-880 and radiation were combined simultaneously, with combination indices around 0.7.• In long-term survival assays, we demonstrated a radiosensitizing effect of APG-880 with dose enhancement factors between 1.3 and 1.5.
Journal Title: Clinical and Translational Radiation Oncology
Year Published: 2020
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