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Dose-dependent volume loss in subcortical deep grey matter structures after cranial radiotherapy

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Highlights • Subcortical grey matter is susceptible to dose-dependent volume loss after RT.• Hippocampal age increases 1 year after radiotherapy, by a median of 11 years.• We may need to… Click to show full abstract

Highlights • Subcortical grey matter is susceptible to dose-dependent volume loss after RT.• Hippocampal age increases 1 year after radiotherapy, by a median of 11 years.• We may need to reconsider current sparing strategies in RT for brain tumours.• Future studies should examine the impact of deep GM volume loss on cognition.

Keywords: volume; dependent volume; grey matter; dose dependent; volume loss

Journal Title: Clinical and Translational Radiation Oncology
Year Published: 2021

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