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Longitudinal characterization of the tumoral microbiome during radiotherapy in HPV-associated oropharynx cancer

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Highlights • The microbiome of HPV+ oropharynx cancer exhibits reduced alpha diversity during radiotherapy.• The baseline tumor bacterial profiles of smokers vs. non-smokers are inherently different.• Eark High baseline alpha… Click to show full abstract

Highlights • The microbiome of HPV+ oropharynx cancer exhibits reduced alpha diversity during radiotherapy.• The baseline tumor bacterial profiles of smokers vs. non-smokers are inherently different.• Eark High baseline alpha diversity may predict early response to radiation and should be investigated.• Alteration of the tumor microbiome composition occurs as early as in the first week of radiotherapy.

Keywords: longitudinal characterization; characterization tumoral; radiotherapy; microbiome; oropharynx cancer

Journal Title: Clinical and Translational Radiation Oncology
Year Published: 2021

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