"Endocrine therapy with accelerated Partial breast irradiatiOn or exclusive ultra-accelerated Partial breast irradiation for women aged ≥ 60 years with Early-stage breast cancer (EPOPE): The rationale for a GEC-ESTRO randomized phase III-controlled trial"

Endocrine therapy with accelerated Partial breast irradiatiOn or exclusive ultra-accelerated Partial breast irradiation for women aged ≥ 60 years with Early-stage breast cancer (EPOPE): The rationale for a GEC-ESTRO randomized phase III-controlled trial

Highlights • Epidemiologic data confirm the increase of breast cancer incidence in the elderly.• The risk of recurrence of breast cancer is basically low.• De-escalation breast cancer adjuvant therapy is justified in selected elderly patients.• Ultra-accelerated breast irradiation with endocrine therapy omission is under debate.• Prospective randomized trial is warranted.

Keywords: breast irradiation; accelerated partial; breast; breast cancer; partial breast

Journal Title: Clinical and Translational Radiation Oncology
Year Published: 2021

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