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Autophagosome Formation: Cutting the Gordian Knot at the ER

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Autophagosome biogenesis and the origins of its isolation membrane have been a long-standing unresolved question, with the endoplasmic reticulum and its membrane contact sites with other organelles remaining the prime… Click to show full abstract

Autophagosome biogenesis and the origins of its isolation membrane have been a long-standing unresolved question, with the endoplasmic reticulum and its membrane contact sites with other organelles remaining the prime suspect. This concept has now been reinforced by recent advances uncovering roles of several ER membrane proteins in autophagosome formation.

Keywords: formation cutting; formation; cutting gordian; membrane; gordian knot; autophagosome formation

Journal Title: Current Biology
Year Published: 2018

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