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Disease Tolerance: Linking Sickness Behaviours to Metabolism Helps Mitigate Malaria

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Malaria-infected mice exhibit a range of sickness behaviours, and experience metabolic shifts and physiological pathologies that result in reduced energy expenditure. Treating sick mice with glucose increases disease tolerance by… Click to show full abstract

Malaria-infected mice exhibit a range of sickness behaviours, and experience metabolic shifts and physiological pathologies that result in reduced energy expenditure. Treating sick mice with glucose increases disease tolerance by improving the physiological and behavioural symptoms of malaria infection without affecting parasite loads.

Keywords: linking sickness; sickness behaviours; disease tolerance; tolerance linking

Journal Title: Current Biology
Year Published: 2018

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