LAUSR

Background The IL‐10 dependent regulatory function of B cells had recently more and more investigated and play important roles in cancer immunity, however, beyond IL‐10 whether other inhibitory cytokines play an important role in cancer is lacking. Here, we investigated the role of IL‐35 producing B cells in colorectal cancer (CRC). Methods Thirty‐two healthy controls (HC) and 49 untreated CRC patients were enrolled and the IL‐35 producing B cells in the peripheral blood were investigated. Additionally, CD4+CD25+/highCD127low/− regulatory T (Treg) and CD14+HLA‐DRlow/− myeloid‐derived suppressor cells (MDSCs) were also investigated. Results Results show that IL‐35 producing B cells were significantly upregulated during the clinical progression of CRC, and negatively correlated with CD3+ T cell, positively correlated with the frequency of CD4+CD25+/highCD127low/− Treg cells and CD14+HLA‐DRlow/− MDSCs of these CRC patients. Conclusions Together, IL‐35 producing B cells were significantly elevated in CRC, indicating this B cell subset might participate in the immune suppression of CRC.