LAUSR

&NA; The study aimed to determine whether circulating spexin (SPX) is modified during the course of pregnancy and whether it is affected by the presence of glucose intolerance, i.e., Gestational Diabetes Mellitus (GDM). This prospective study included 102 pregnant women (63 non‐GDM and 39 GDM; mean age 29.4 ± 5.1 years; mean BMI 28.0 ± 6.1 kg/m2). Anthropometrics, glycemic and lipid profiles, as well measurements of circulating adipocytokines and SPX were measured at baseline and after 3 and 6 months. In GDM patients, SPX levels increased significantly after 6‐months, in parallel with a borderline significant increase in glucose (p = 0.07). In non‐GDM patients, however, median SPX level decreased from baseline to 6‐months (p < 0.01), and this change was not associated with changes in glucose levels. Change in glucose from baseline to 6‐months was positively associated with change in SPX in GDM patients only (R = 0.37; p < 0.05). SPX levels are positively influenced by glucose intolerance in pregnant women with GDM, while they decrease in control women without GDM.