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Adolescent pruning and stabilization of dendritic spines on cortical layer 5 pyramidal neurons do not depend on gonadal hormones

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Highlights • Spines in frontal cortex of female mice are pruned and stabilized during adolescence.• Pre-pubertal hormone exposure does not accelerate spine pruning and stabilization.• Pre-pubertal gonadectomy does not prevent… Click to show full abstract

Highlights • Spines in frontal cortex of female mice are pruned and stabilized during adolescence.• Pre-pubertal hormone exposure does not accelerate spine pruning and stabilization.• Pre-pubertal gonadectomy does not prevent spine pruning and stabilization.• Pre-pubertal hormone exposure and gonadectomy do impact spine morphology.

Keywords: pre pubertal; stabilization; pruning stabilization; adolescent pruning; stabilization dendritic; dendritic spines

Journal Title: Developmental Cognitive Neuroscience
Year Published: 2018

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