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PLD and PA Take MT1-MMP for a Metastatic Ride.

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Polarized targeting and deposition of MT1-MMP is pivotal for metastasis. In this issue of Developmental Cell, Wang et al. (2017) reveal that a signaling molecule generated by phospholipase D2 drives deposition of… Click to show full abstract

Polarized targeting and deposition of MT1-MMP is pivotal for metastasis. In this issue of Developmental Cell, Wang et al. (2017) reveal that a signaling molecule generated by phospholipase D2 drives deposition of MT1-MMP at the site of invadopodia formation and is critical for metastasis in a transgenic breast cancer model.

Keywords: mt1; mt1 mmp; pld take; take mt1; mmp metastatic

Journal Title: Developmental cell
Year Published: 2017

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