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Versatile Scaffold: Extrajunctional Roles for α-Catenin.

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α-catenin is a scaffolding molecule that can bind F-actin and other cytoskeletal proteins. It is best known for its contribution to cell-cell adhesion. In this issue of Developmental Cell, Vassilev… Click to show full abstract

α-catenin is a scaffolding molecule that can bind F-actin and other cytoskeletal proteins. It is best known for its contribution to cell-cell adhesion. In this issue of Developmental Cell, Vassilev et al. (2017) identify an extrajunctional pool of α-catenin that regulates RhoA signaling and controls directional migration of single cells.

Keywords: extrajunctional roles; versatile scaffold; scaffold extrajunctional; cell; roles catenin

Journal Title: Developmental cell
Year Published: 2017

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