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Exploring the Function of Dynamic Phosphorylation-Dephosphorylation Cycles.

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Protein phosphorylation is a dynamic post-translational modification critical for biological responses. At the level of individual molecules, phosphorylation dynamics can have important functional implications, but this information is rarely quantified.… Click to show full abstract

Protein phosphorylation is a dynamic post-translational modification critical for biological responses. At the level of individual molecules, phosphorylation dynamics can have important functional implications, but this information is rarely quantified. We discuss how rapid phosphorylation-dephosphorylation cycles could underlie important signaling properties, including the ability to rapidly bind and release proteins.

Keywords: function dynamic; phosphorylation dephosphorylation; dephosphorylation cycles; exploring function; phosphorylation

Journal Title: Developmental cell
Year Published: 2018

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