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Synaptotagmins Tweak Functional β Cell Maturation.

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Immature β cells secrete insulin at a lower glucose threshold compared to mature β cells. In this issue of Developmental Cell, Huang et al. (2018) show that the increase in glucose… Click to show full abstract

Immature β cells secrete insulin at a lower glucose threshold compared to mature β cells. In this issue of Developmental Cell, Huang et al. (2018) show that the increase in glucose threshold during β cell maturation is achieved through balance between the Ca2+-sensitive synaptotagmin 7 and the Ca2+-insensitive synaptotagmin 4.

Keywords: synaptotagmins tweak; cell maturation; tweak functional; cell; functional cell

Journal Title: Developmental cell
Year Published: 2018

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