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Chromosome Segregation Fidelity Integrates Information across Scales.

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The influence of tissue context is an emerging theme in cell biology. Recent work reveals that tissue architecture promotes chromosome segregation fidelity in epithelia, suggesting that aneuploidy in certain cancers… Click to show full abstract

The influence of tissue context is an emerging theme in cell biology. Recent work reveals that tissue architecture promotes chromosome segregation fidelity in epithelia, suggesting that aneuploidy in certain cancers may arise as a consequence of disrupted tissue architecture and highlighting the shortcomings of cell culture systems.

Keywords: integrates information; segregation fidelity; chromosome segregation; fidelity integrates

Journal Title: Developmental cell
Year Published: 2018

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