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DNA cross-linking agents are common chemotherapeutics for cancer treatment, but their effect on normal cells is largely unknown. In this issue of Developmental Cell, Seldin and Macara (2020) show that… Click to show full abstract
DNA cross-linking agents are common chemotherapeutics for cancer treatment, but their effect on normal cells is largely unknown. In this issue of Developmental Cell, Seldin and Macara (2020) show that such compounds induce epithelial hyperplasia and stem cell fate mis-specification in a non-cell-autonomous manner via inflammasome activation in dermal fibroblasts.
Keywords:
unexpected effect;
genotoxic agents;
healthy epithelia;
effect;
agents unexpected;
effect healthy
Journal Title: Developmental cell
Year Published: 2020
Link to full text (if available)
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Journal Title: Developmental cell
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!