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Cells under Tension Drive Gastrulation.

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In this issue of Developmental Cell, Muncie et al. describe the generation of gastrulation-like foci of cells within micropatterned colonies of pluripotent stem cells. This demonstration of mechanosensitive β-catenin/Wnt-dependent specification of… Click to show full abstract

In this issue of Developmental Cell, Muncie et al. describe the generation of gastrulation-like foci of cells within micropatterned colonies of pluripotent stem cells. This demonstration of mechanosensitive β-catenin/Wnt-dependent specification of cell fate during gastrulation illustrates the insights gleaned by placing stem cells in embryo-like mechanical environments.

Keywords: cell; tension drive; cells tension; gastrulation; drive gastrulation

Journal Title: Developmental cell
Year Published: 2020

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