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Loss of imprinting (LOI) at the Dlk1-Dio3 locus is linked to Kagami-Ogata and Temple syndromes, and to cancer, but molecular mechanisms that prevent LOI are under-studied. In this issue of… Click to show full abstract
Loss of imprinting (LOI) at the Dlk1-Dio3 locus is linked to Kagami-Ogata and Temple syndromes, and to cancer, but molecular mechanisms that prevent LOI are under-studied. In this issue of Developmental Cell, Aronson et al. demarcate the bipartite regulation of the Dlk1-Dio3 imprinting control region (ICR) IG-DMR, which maintains locus imprinting.
Keywords:
story imprinting;
two sides;
dio3 story;
dlk1 dio3;
sides dlk1
Journal Title: Developmental cell
Year Published: 2021
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Journal Title: Developmental cell
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!