LAUSR

AIMS Serum triglyceride to high-density lipoprotein cholesterol(TG/HDL-C) ratio is known to be associated with cardiometabolic diseases. This study is aimed to evaluate the association between the TG/HDL-C ratio and incident type 2 diabetes with a large-sample, community-based Korean cohort over 12 years. METHODS Among 10,038 participants, a total of 8,655 participants aged 40 to 69 years without diabetes were selected from the Korean Genome and Epidemiology Study(KoGES). The baseline TG/HDL-C ratio was divided into quartiles. Newly developed type 2 diabetes was defined by any of the following: a fasting plasma glucose level ≥126 mg/dL; a glucose level ≥200 mg/dL 2-hours after a 75g oral glucose tolerance test; an HbA1c ≥ 6.5 %; or treatment with anti-diabetic therapy. The hazard ratios(HRs) with 95% confidence intervals(CIs) for incident type 2 diabetes were calculated using multivariate Cox proportional hazards regression models after adjusting for potentially confounding variables. RESULTS During the 12-year follow-up period, type 2 diabetes developed in 1,437 subjects (16.6%, 1437/8655), with incidence rate of 2.8-5.0 (over 2 years). Compared to the reference first quartile, the HRs (95% CIs) of incident type 2 diabetes in the second, third, and fourth quartiles increased in a dose-response manner after adjusting for potentially confounding variables. CONCLUSIONS High TG/HDL-C ratio at baseline may be a useful surrogate indicator of future incident type 2 diabetes.