AIMS Studies using contemporary cohorts are needed to assess the association between type 2 diabetes and cancer. METHODS Using the United Kingdom Clinical Practice Research Datalink, we matched patients with… Click to show full abstract
AIMS Studies using contemporary cohorts are needed to assess the association between type 2 diabetes and cancer. METHODS Using the United Kingdom Clinical Practice Research Datalink, we matched patients with type 2 diabetes between 1988 to 2019 to patients without type 2 diabetes. Poisson regression models were fit to estimate incidence rate ratios (IRRs) with 95% confidence intervals (CIs) for cancer. In secondary analyses, we determined whether the strength of the association varied with calendar time and whether patients with type 2 diabetes had a higher incidence of being diagnosed with multiple cancers during the follow-up period. RESULTS 890,214 patients with type 2 diabetes were matched to an equal number of patients without type 2 diabetes. Patients with type 2 diabetes had a higher cancer incidence than patients without type 2 diabetes (IRR 1.19, 95% CI 1.18-1.21). The IRR was higher 2010 onwards (IRR: 1.25, 95% CI: 1.23-1.28) compared with the association in previous years. Overall, patients with type 2 diabetes had a 5% higher incidence of being diagnosed with multiple cancers (IRR: 1.05, 95% CI: 1.04-1.07). CONCLUSIONS The results of this large population-based study indicate that type 2 diabetes is associated with an increased risk of several cancers.
               
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