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Daptomycin β-Lactam combination therapy offers "protection" against daptomycin non-susceptibility (DNS) development in Enterococcus faecium. We report failure of this strategy and the importance of source control. Mutations were detected in… Click to show full abstract
Daptomycin β-Lactam combination therapy offers "protection" against daptomycin non-susceptibility (DNS) development in Enterococcus faecium. We report failure of this strategy and the importance of source control. Mutations were detected in the LiaF and cls genes in DNS isolates. A single DNS isolate contained an unrecognized mutation, which requires confirmation.
Keywords:
lactam combination;
combination therapy;
daptomycin lactam;
enterococcus faecium
Journal Title: Diagnostic microbiology and infectious disease
Year Published: 2018
Link to full text (if available)
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Journal Title: Diagnostic microbiology and infectious disease
Year Published: 2018
Link to full text (if available)
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recommendations!