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Prolonged linezolid use is associated with the development of linezolid-resistant Enterococcus faecium.

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We assessed risk factors for and outcomes of linezolid-resistant vancomycin-resistant Enterococcus faecium (LRVREF) bacteremia over 7 years. Thirty-four LRVREF cases were matched to 68 linezolid-susceptible VREF controls. The odds of… Click to show full abstract

We assessed risk factors for and outcomes of linezolid-resistant vancomycin-resistant Enterococcus faecium (LRVREF) bacteremia over 7 years. Thirty-four LRVREF cases were matched to 68 linezolid-susceptible VREF controls. The odds of bacteremia with LRVREF increased by 7% for each additional day of prior linezolid exposure.

Keywords: enterococcus faecium; prolonged linezolid; resistant enterococcus; linezolid resistant

Journal Title: Diagnostic microbiology and infectious disease
Year Published: 2018

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