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In vitro evaluation of antifungal combination against Cryptococcus neoformans.

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This study evaluated combinations of amphotericin B with anidulafungin, caspofungin, and micafungin against 30 clinical isolates of Cryptococcus neoformans following the CLSI M27-A3 and the checkerboard microdilution method. The combination… Click to show full abstract

This study evaluated combinations of amphotericin B with anidulafungin, caspofungin, and micafungin against 30 clinical isolates of Cryptococcus neoformans following the CLSI M27-A3 and the checkerboard microdilution method. The combination amphotericin B + micafungin showed 60% of synergistic effect against C. neoformans, while most of the other interactions were indifferent.

Keywords: combination; cryptococcus neoformans; vitro evaluation; antifungal combination; evaluation antifungal; combination cryptococcus

Journal Title: Diagnostic microbiology and infectious disease
Year Published: 2019

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