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SARS-CoV-2 N gene mutations impact detection by clinical molecular diagnostics: reports in two cities in the United States

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Nasal and nasopharyngeal swab specimens tested by the Cepheid Xpert Xpress SARS-CoV-2 were analyzed by whole-genome sequencing based on impaired detection of the N2 target. Each viral genome had at… Click to show full abstract

Nasal and nasopharyngeal swab specimens tested by the Cepheid Xpert Xpress SARS-CoV-2 were analyzed by whole-genome sequencing based on impaired detection of the N2 target. Each viral genome had at least one mutation in the N gene, which likely arose independently in the New York City and Pittsburgh study sites.

Keywords: detection; gene mutations; mutations impact; cov gene; sars cov

Journal Title: Diagnostic Microbiology and Infectious Disease
Year Published: 2021

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