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Bioanalysis to support PK-PD studies and clinical trials can be challenging especially when quantifying highly potent compounds. In this study, quantitation attributes were determined for a set of drug-like compounds… Click to show full abstract
Bioanalysis to support PK-PD studies and clinical trials can be challenging especially when quantifying highly potent compounds. In this study, quantitation attributes were determined for a set of drug-like compounds in human plasma using microflow LC and high resolution mass spectrometry (HRMS) with ionKey/MS and the Xevo G2XS Time of Flight (Tof) mass spectrometer. The iKey is a microflow separation device which is compatible with Waters Tandem and QTof platforms. The Xevo-G2XS QTof is the latest QTof instrument with enhanced resolution and sensitivity compared to its predecessor. The combined use of both technologies yields an extremely sensitive LC/HRMS instrument. Addition of a trap-and-elute configuration enables the system to handle analytical scale sample volume injection while maintaining excellent peak shape, which further enhances the system's sensitivity. High Sensitivity Bioanalysis for Small Drug-Like Compounds in Human Plasma using Microflow LC and High Resolution Mass Spectrometry
Journal Title: Drug Metabolism and Pharmacokinetics
Year Published: 2017
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