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Human herpes simplex viruses (HSV) belong to the Herpesviridae family. At present, no vaccine or curative treatment is available for the prevention of HSV infections. Here, we review the cell… Click to show full abstract
Human herpes simplex viruses (HSV) belong to the Herpesviridae family. At present, no vaccine or curative treatment is available for the prevention of HSV infections. Here, we review the cell surface receptors that are recognized by HSV's glycoprotein B, glycoprotein C, glycoprotein D, and the glycoprotein H - glycoprotein L complex to facilitate entry into host cells. These receptors include heparan sulfate (HS), herpesvirus entry mediator (HVEM), and nectin-1/-2, 3-O-sulfated heparan sulfate (3-OS HS).
Keywords:
receptors ligands;
drug;
herpes simplex;
glycoprotein glycoprotein;
simplex viruses
Journal Title: Drug discovery today
Year Published: 2021
Link to full text (if available)
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Journal Title: Drug discovery today
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!