LAUSR

BACKGROUND Testosterone (T) is taken or prescribed to enhance appearance, increase athletic performance and libido and to treat hypogonadism. Digit ratio (2D:4D) is thought to be a negative correlate of prenatal T. Here we consider the relationship between 2D:4D and T supplementation. AIMS Our sample was taken from the BBC internet study. Respondents were asked (y/n) if they were taking; (i) T, (ii) hormone replacement therapy with T (HRTwT). We removed extreme 2D:4D values and age and considered the most numerous ethnic group (i.e. "Whites"). Analyses were performed with a two-factor (sex*T) analysis of variance with covariate age and dependent variables 2D:4D or right-left 2D:4D (Dr-l). RESULTS Out of 197,589 respondents, 793 (598 males) reported taking T. There was a significant main effect for right 2D:4D such that T supplementing males had higher 2D:4D than those who did not. The sex*T interaction was significant, but the effect reversed in females. There were 22,576 (661 males) participants who reported taking HRTwT. We found a significant main effect for right 2D:4D, males taking HRTwT had higher 2D:4D than those who did not. This was reversed in females. The sex*HRTwT interaction was significant, a high Dr-l was also found in males reporting HRTwT. CONCLUSION Males who reported taking T or HRTwT had high right 2D:4D and/or Dr-l. The situation with females may be the reverse of that found in males but effect sizes are less. The health implications of an association between high (feminized) 2D:4D and T supplementation in males are discussed.