LAUSR

BACKGROUND Nickel, as one of the most abundant elements in the earth's crust, plays many roles in human reproduction and life. It is an essential trace element for the human body, but can be harmful in excess amounts. Nickel has a significant impact on endocrine hormones in humans and animals, potentially causing abnormal secretions and changing the structure and function of endocrine organs. This article systematically reviews the effects of nickel on hormone secretion and target organs in the endocrine system and identifies areas of insufficient research. METHODS All data in this article were extracted from peer-reviewed articles. The PubMed, SciFinder, Google Scholar, Web of Science, and China National Knowledge Infrastructure databases were searched for relevant articles. Data on nickel's effect on endocrine system hormones and target organs were retrieved, and manually sorted prior to inclusion in this review. RESULTS Nickel acts on the endocrine system and affects the release and regulation of endocrine hormones. Disorders of endocrine hormones may lead to retardation of human growth and mental development, disturbance of water and salt regulation, and even a decline in reproductive ability. Nickel affects the hypothalamus and pituitary gland by regulating organs upstream of the endocrine axis; it can cause abnormal secretion of pituitary hormones, which affects target organs of the endocrine axis, resulting in dysfunction therein and abnormal secretion of related hormones. Nickel also damages target organs, mainly by inducing apoptosis, which triggers oxidative stress, cell autophagy, free radical release, and DNA damage. However, there are few studies on the endocrine axis, and some of the data are contradictory. Nevertheless, it is clear that nickel affects the endocrine system. CONCLUSIONS Nickel can damage organs in the endocrine system, such as the hypothalamus and pituitary. It also affects the secretion of hormones and damages the target organs of these hormones; this can result in endocrine system dysfunction. However, the results have been equivocal and further research is needed.